Mushroom component may be effective against Covid-19

For a recent study, researchers screened and validated molecules from passenger chairs for their activity against the major protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

The Covid-19 pandemic is still not over and continues. exert significant pressure on the healthcare sector worldwide. The emergence of mutated SARS-Cov-2 variants and the lack of universally authorized therapeutic agents contribute to the continuing increase in SARS-Cov-2 related morbidity and death. The Mpro of SARS-Cov-2 is an important therapeutic target for drug development against Covid-19. Mushrooms, and ingredients extracted from them, are known for their medicinal properties. They possess anti-inflammatory, antibacterial and antiviral properties. Despite this, the efficacy of mushroom constituents for the treatment of SARS-CoV-2 has not yet been extensively studied. For the particular study, the SARS-CoV-2 Mpro binding affinity of components from the C. militaris (a mushroom species) was examined and the component with the strongest affinity selected. The Cordycepin interaction was assessed by MD simulation. The results showed that the Cordycepin from the C. militaris was the most active molecule against the SARS-CoV-2 Mpro.

Shiitake